Analyzing synergistic and non-synergistic interactions in signalling pathways using Boolean Nested Effect Models
نویسندگان
چکیده
منابع مشابه
Analyzing synergistic and non-synergistic interactions in signalling pathways using Boolean Nested Effect Models
MOTIVATION Understanding the structure and interplay of cellular signalling pathways is one of the great challenges in molecular biology. Boolean Networks can infer signalling networks from observations of protein activation. In situations where it is difficult to assess protein activation directly, Nested Effect Models are an alternative. They derive the network structure indirectly from downs...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2015
ISSN: 1460-2059,1367-4803
DOI: 10.1093/bioinformatics/btv680